What is Zellweger Syndrome?
Zellweger Syndrome is one of a group of four related disseases called peroxisome biogenesis disorder (PBD) wich are part of a larger group of diseases known as Leukodystrophies. These are inherited conditions that damage the white matter of the brain and also affect how the body metabolizes the particular substaces in the blood and organ tissues. Zellweger Syndrome is the most severe of the PBDs. Infantile Refsum Disease (IRD) is the mildest and Neonatal adrenoleukodystrophy and rhizmelic Chondrodysplasia have similar but less severe symptoms. The PBDs are caused by defects in genes that are active in brain development and the formation of myelin the whitish substance found in the cerebral cortex area of the brain. After birth, defects in the same genes reduce or eliminate the presence of peroxisomes - cell structures that break down toxic substances in the cells of the liver, kidneys, and brain. As a result in Zellweger Syndrome, high levels of iron and copper build up in the blood and tissue and cause the characteristic symptoms of the disease. These symptoms include an enlarged liver, facial deformities such as a high fore head, under developed eyebrow ridges and deformed ear lobes and neurological deformities such as mental retardation and seizures. Infants with Zellweger Syndrome also lack muscle tone, sometimes to the point of being unable to move, and may not suck or swallow. Some babies will be born with glaucoma, retinal degeneration, and impaired hearing. Jaundice and gastrointestinal bleeding may also occur.
Is there any treament?
There is no cure for Zellweger Syndrome, nor is there a standard cource of treatment. Since the metabolic and neurological abnormalities that cause the symptoms of Zellweger Syndrome are caused during fetal development, treatment to correct these abnormalities after birth are limited. Most treatments are symtomatic and supportive.
What is the Prognosis?
The prognosis for infants with Zellweger Syndrome is poor, MOST infants do not survive past the first six months and usually succumb to respatory destress, gastrointestinal bleeding or liver failure.
What research is being done?
In the USA, The National Institute of Neurological Disorders and Stroke (NINDS) and other institutes of the National Institutes of Health (NIH), conduct research exploring the molecular and genetic basis of Zellweger Syndrome and other PBDs in laboratories at the NIH, and also support additional research through grants of major medical institutions across the country. Much of this research focuses on finding better ways to prevent treat and ultimately cure disorders such as Zellweger Syndrome.